Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening
Our work demonstrates that integrating transcriptomics with targeted orthogonal assays in a tiered framework can support Next Generation Risk Assessment by informing putative molecular targets and prioritizing chemicals for further testing. https://doi.org/10.1289/EHP16024.
Authors
- Katie Paul Friedman (ORCID: https://orcid.org/0000-0002-2710-1691)
- Jesse D. Rogers (ORCID: https://orcid.org/0000-0001-6667-2342)
- Logan J. Everett (ORCID: https://orcid.org/0000-0002-9713-6099)
- Richard Judson (ORCID: https://orcid.org/0000-0002-2348-9633)
- Joshua Harrill (ORCID: https://orcid.org/0000-0003-4317-6391)
- Joseph L. Bundy (ORCID: https://orcid.org/0000-0002-7631-6197)
Institutions
- Oak Ridge Associated Universities (US)
- Oak Ridge Institute for Science and Education
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1289/ehp16024
- Citations
- 5
- Primary Topic
- Viral Infectious Diseases and Gene Expression in Insects
- Type
- article
- Field-Weighted Citation Impact
- 4.03