Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
Dio could inhibit the proliferation and promote apoptosis of GBM cells, and play a significant inhibitory role in tumor growth. Dio could affect the phosphorylation of EGFR and then trigger the apoptosis process, resulting in the up-regulation of apoptosis protein CASP3 expression in GBM cells.
Authors
- Zhongdong Hu (ORCID: https://orcid.org/0000-0003-4849-3353)
- Qi Xiang (ORCID: https://orcid.org/0000-0001-9790-5823)
- Tingting Li (ORCID: https://orcid.org/0000-0001-6041-6719)
- Hongxia Chen (ORCID: https://orcid.org/0000-0003-2331-0880)
- Jianhui Huang
- Caiyun Jiang
Institutions
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Peking University Shenzhen Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Open Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1515/med-2025-1194
- Citations
- 1
- Primary Topic
- Phytochemical Studies and Bioactivities
- Type
- article
- Field-Weighted Citation Impact
- 0.81