Diagnostic performance of particle-based multi-analyte technology compared to indirect immunofluorescence in screening for anti-nuclear antibodies in patients with autoimmune rheumatic diseases
This is the first study comparing Aptiva/PMAT against HEp-2 IIF in ANA detection. While the diagnostic sensitivity of this novel method is lower than that of HEp-2 IIF, its high specificity is a valuable tool in the diagnosis of patients affected by ARD and improves their stratification into specific disease subsets. The combined use of HEp-2 IIF and Aptiva/PMAT assays increases diagnostic accuracy and significantly enhances the potential to accurately classify patients affected by ARDs.
Authors
- Elena Bartoloni (ORCID: https://orcid.org/0000-0003-4776-2136)
- Nicola Bizzaro (ORCID: https://orcid.org/0000-0002-4227-6983)
- Giulia Previtali (ORCID: https://orcid.org/0000-0003-3837-6890)
- Francesca Buzzulini (ORCID: https://orcid.org/0000-0002-1498-6443)
- Giacomo Cafaro (ORCID: https://orcid.org/0000-0003-1774-1916)
- Roberto Gerli (ORCID: https://orcid.org/0000-0002-4684-575X)
- Danilo Villalta (ORCID: https://orcid.org/0000-0002-8865-4150)
- Maria Grazia Alessio (ORCID: https://orcid.org/0000-0002-3567-7332)
Institutions
- University of Perugia (IT)
- Azienda Ospedaliera Santa Maria Degli Angeli (IT)
Publication Details
- Journal
- Clinical and Experimental Rheumatology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.55563/clinexprheumatol/h03g16
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00