Pilot-Scale Preparation of Broad-Spectrum CBD: Extraction Optimization and Purification using Centrifugal Partition Chromatography
BBD-RSM optimization of ethanolic cannabis extraction provided the highest cannabinoid concentration with a short extraction time and desirable appearance. The CPC process successfully separated Δ<sup>9</sup>-THC, yielding a high-purity broad-spectrum CBD extract.
Authors
- Neti Waranuch (ORCID: https://orcid.org/0000-0001-7476-7288)
- Panatpong Boonnoun
- Tongchai Saesong
- Nattakanwadee Khumpirapang (ORCID: https://orcid.org/0000-0001-9069-4509)
- Eakkaluk Wongwad (ORCID: https://orcid.org/0000-0003-4538-0441)
- Kornkanok Ingkaninan (ORCID: https://orcid.org/0000-0002-4415-8489)
- Prapapan Temkitthawon (ORCID: https://orcid.org/0000-0002-8442-3347)
- Vorawut Wongumpornpinit
- Sujittra Paenkaew
Institutions
- University of Phayao (TH)
- Naresuan University (TH)
Publication Details
- Journal
- Medical Cannabis and Cannabinoids
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1159/000546263
- Citations
- 1
- Primary Topic
- Chromatography in Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- National Research Council of Thailand
- Naresuan University
- Agricultural Research Development Agency
- Center of Excellence for Innovation in Chemistry