Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression
Smoking-induced GAPDH succinylation coordinates glycolysis and glutamine metabolism and supports lung cancer cell survival in stressful microenvironments to promote tumor progression, highlighting quitting smoking as a potential strategy to target cancer metabolism.
Authors
- Jing Zhang (ORCID: https://orcid.org/0000-0001-7719-6943)
- Gang Nan (ORCID: https://orcid.org/0000-0002-7926-4572)
- Jian‐Li Jiang (ORCID: https://orcid.org/0000-0001-7952-5667)
- Qing-zhi Ma (ORCID: https://orcid.org/0009-0005-8813-4621)
- Qing-mei Zeng (ORCID: https://orcid.org/0000-0002-6276-9603)
- Zhi‐Nan Chen (ORCID: https://orcid.org/0000-0001-5512-4623)
- Liang Chen
- Ming Zhao (ORCID: https://orcid.org/0000-0003-1093-6817)
- Huai‐Qiang Ju (ORCID: https://orcid.org/0000-0003-1713-5465)
- Hong‐Yong Cui (ORCID: https://orcid.org/0000-0003-0051-2666)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6052-0321)
- Wan Huang
- Qiu-zi Yang
- Kun Wang (ORCID: https://orcid.org/0000-0002-3477-283X)
- Yiming Li (ORCID: https://orcid.org/0000-0003-3251-0104)
- Hongyan Ma
- Minxie Qian
- Lin Jing (ORCID: https://orcid.org/0009-0001-5925-0253)
- Hai Zhang (ORCID: https://orcid.org/0000-0002-7999-0208)
- Jingzhuo Li (ORCID: https://orcid.org/0009-0007-9971-7202)
- Xiuxuan Sun
- Jie Zou
- Cai-feng Xiong
Institutions
- Shanghai University (CN)
- Target (United States) (US)
- Shanghai University of Engineering Science (CN)
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Xijing Hospital (CN)
- New York University Langone Orthopedic Hospital (US)
- Air Force Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3525
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China