Goblet Cell Loss Linked to NOD2 and Secondary Resection in Crohn’s Disease Is Induced by Dysbiosis and Epithelial MyD88
Goblet cell defects may be a harbinger of small intestinal inflammation in patients with CD, particularly in the postoperative setting. Our findings in mice show that small intestinal goblet cell loss associated with Nod2 mutation is induced by microbiome dysbiosis and epithelial MyD88, in part due to TLR4 signaling.
Authors
- Serre-Yu Wong (ORCID: https://orcid.org/0000-0002-2070-4123)
- Yi� Ding (ORCID: https://orcid.org/0000-0001-5035-9255)
- Deepshika Ramanan (ORCID: https://orcid.org/0000-0003-1029-8042)
- Adriana Rosas-Villegas (ORCID: https://orcid.org/0000-0001-9114-0882)
- Judy H. Cho
- Scott G. Daniel (ORCID: https://orcid.org/0000-0002-7441-923X)
- Kyung Ku Jang (ORCID: https://orcid.org/0000-0002-0403-1256)
- María Manuela Estevinho (ORCID: https://orcid.org/0000-0001-7171-0139)
- T. G. Heaney (ORCID: https://orcid.org/0000-0003-4909-6851)
- Ken Cadwell (ORCID: https://orcid.org/0000-0002-5860-0661)
- Huaibin M. Ko (ORCID: https://orcid.org/0000-0003-1062-2383)
- Hairu Yang (ORCID: https://orcid.org/0000-0002-9420-878X)
- Kyle Bittinger (ORCID: https://orcid.org/0000-0003-3472-5934)
- A. Marshall
- Elisabeth Giselbrecht
- Chaoting Zhou
- John D. Paulson (ORCID: https://orcid.org/0000-0002-3361-2818)
- James D. Lewis
Institutions
- Geisinger Medical Center (US)
- Salk Institute for Biological Studies (US)
- Children's Hospital of Philadelphia (US)
- Universidade do Porto (PT)
- Yonsei University (KR)
- Columbia University Irving Medical Center (US)
- New York University (US)
- University of Pennsylvania (US)
- Rockefeller University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101533
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Crohn's and Colitis Foundation of America
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- American College of Gastroenterology
- National Institutes of Health