Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study
Using GWAS, MKLN1 and MMP14 were found to be associated with CRC development and we identified GW0742 (PPARβ/δ agonist) as a potential drug-repositioning candidate for CRC based on MKLN1 and MMP14. These findings improve the understanding of CRC development and provide insights into novel therapeutic targets and candidates for CRC treatment.
Authors
- Sun‐Seog Kweon (ORCID: https://orcid.org/0000-0003-2378-8550)
- Aesun Shin (ORCID: https://orcid.org/0000-0002-6426-1969)
- Jung-Ho Yang (ORCID: https://orcid.org/0000-0002-1581-8425)
- Nan Song (ORCID: https://orcid.org/0000-0002-9182-1060)
- Dabin Yun
- Jin-Ah Sim (ORCID: https://orcid.org/0000-0002-3494-3002)
- Ji Won Park (ORCID: https://orcid.org/0000-0003-0046-8175)
- Min Jung Kim (ORCID: https://orcid.org/0000-0002-3105-9633)
- Seung Yong Jeong
Institutions
- Seoul National University (KR)
- Hallym University (KR)
- Chungbuk National University (KR)
- Seoul National University Hospital (KR)
- Chonnam National University Hwasun Hospital (KR)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s12967-025-06491-6
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mike and Josie Harper Cancer Research Institute
- National Research Foundation
- Chonnam National University
- Seoul National University
- Ministry of Education
- Seoul National University Hospital
- Ministry of Science and ICT, South Korea
- Chonnam National University Hwasun Hospital