Detection of Early-Stage Colorectal Cancer Using Cell-Free oncRNA Biomarkers and Artificial Intelligence
Our oncRNA-based blood test, powered by artificial intelligence, offers strong performance for early colorectal cancer detection, including in stage I disease for which existing blood-based assays are limited. These findings support further development toward a minimally invasive colorectal cancer screening tool.
Authors
- Lisa Fish (ORCID: https://orcid.org/0000-0001-9184-0512)
- Fereydoun Hormozdiari (ORCID: https://orcid.org/0000-0003-2703-9274)
- Selina Chen
- Akshaya Krishnan
- Alexx J. Smith
- Jeremy Ku
- Babak Alipanahi (ORCID: https://orcid.org/0000-0001-8216-7178)
- Magdalena Gębala (ORCID: https://orcid.org/0000-0002-1086-5548)
- Babak Behsaz (ORCID: https://orcid.org/0000-0003-3313-0322)
- Nae-Chyun Chen (ORCID: https://orcid.org/0000-0002-4140-4568)
- Mehran Karimzadeh (ORCID: https://orcid.org/0000-0002-7324-6074)
- Amir Momen-Roknabadi (ORCID: https://orcid.org/0000-0001-6233-1401)
- Sandeep Sekhon
- Taylor B. Cavazos (ORCID: https://orcid.org/0000-0003-3537-2608)
- Anna Vilborg (ORCID: https://orcid.org/0000-0003-0917-9062)
- Jieyang Wang
- Lee S. Schwartzberg (ORCID: https://orcid.org/0000-0002-7433-3428)
- Ti Lam
- Martha Hernandez (ORCID: https://orcid.org/0009-0007-2575-975X)
- Hani Goodarzi (ORCID: https://orcid.org/0000-0002-9648-8949)
- Jennifer Yen (ORCID: https://orcid.org/0000-0002-8580-220X)
- Helen Li (ORCID: https://orcid.org/0000-0002-1145-6527)
- Jeff Gregg
- Alice Huang
- Rose Hanna
- Dang Nguyen (ORCID: https://orcid.org/0000-0003-1550-4650)
- Alex Degtiar
Institutions
- University of Nevada, Reno (US)
- University of California, San Francisco (US)
- Guardant (United States) (US)
- Palo Alto Institute (US)
- California Ear Institute (US)
- University of California, Davis (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0449
- Citations
- 3
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.81