Human umbilical cord mesenchymal stem cell therapy for atopic dermatitis through inhibition of neutrophil chemotaxis
This study demonstrated that hUC-MSCs and hUC-MSC-CM ameliorate AD-like symptoms, possibly through exosome-dependent suppression of the STAT3 signaling pathway and chemokine expression. Furthermore, hUC-MSC-CM serves as a cell-free alternative to whole-cell therapy, with comparable efficacy, offering novel mechanistic insights and a potential translational strategy for AD treatment.
Authors
- Siming Zhang (ORCID: https://orcid.org/0000-0003-3008-8392)
- Yunxiang Chen (ORCID: https://orcid.org/0000-0002-8219-8262)
- Lijiang Zhang
- Ruolang Pan (ORCID: https://orcid.org/0000-0002-0810-3392)
- Jinjin Shao
- Xiaobo Lin (ORCID: https://orcid.org/0009-0003-5626-5358)
- Zhiqi Xie (ORCID: https://orcid.org/0000-0001-9641-5080)
- Yiru Wang (ORCID: https://orcid.org/0000-0002-8145-4199)
- Ying Chen (ORCID: https://orcid.org/0000-0001-6303-5858)
- Fang Liu (ORCID: https://orcid.org/0000-0002-6742-1446)
- Jiahong Wang (ORCID: https://orcid.org/0000-0002-1811-0465)
- Feifei Wu (ORCID: https://orcid.org/0000-0003-1384-3624)
- Lili Zhang (ORCID: https://orcid.org/0000-0002-1667-4611)
- Guoyu Chen
- Zhichao Ye (ORCID: https://orcid.org/0000-0002-5523-4686)
- Xin Pan (ORCID: https://orcid.org/0000-0001-8852-8050)
- Jinfeng Liang (ORCID: https://orcid.org/0009-0008-2629-9721)
Institutions
- Macau University of Science and Technology (MO)
- National Medical Products Administration (CN)
- Bioscience (China) (CN)
- Zhejiang Academy of Medical Sciences (CN)
- ZheJiang Institute For Food and Drug Control (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Hangzhou Medical College (CN)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s13287-025-04349-8
- Citations
- 3
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 6.01
Funders
- National Natural Science Foundation of China