Genetic variants in tamoxifen metabolism and early treatment discontinuation among premenopausal breast cancer patients
Variants in enzymes responsible for activating tamoxifen metabolites-particularly within CYP2D6-influence early tamoxifen discontinuation. CYP2D6 variants synergistically interact with transporter gene variants, namely ABCC2, to further raise the risk of discontinuation.
Authors
- Lindsay Jane Collin (ORCID: https://orcid.org/0000-0003-0170-2592)
- James W. Baurley (ORCID: https://orcid.org/0000-0003-4116-7723)
- Maret L. Maliniak (ORCID: https://orcid.org/0000-0002-0763-5231)
- Henrik Toft Sørensen (ORCID: https://orcid.org/0000-0003-4299-7040)
- Bent Ejlertsen (ORCID: https://orcid.org/0000-0001-8761-714X)
- Timothy L. Lash (ORCID: https://orcid.org/0000-0002-5240-5195)
- Trine Tramm (ORCID: https://orcid.org/0000-0003-3894-4552)
- Per Damkier (ORCID: https://orcid.org/0000-0003-0591-7187)
- Kirsten M. Woolpert (ORCID: https://orcid.org/0000-0002-5536-7649)
- Deirdre Cronin‐Fenton (ORCID: https://orcid.org/0000-0001-9738-2284)
- Stephen Jacques Hamilton-Dutoit (ORCID: https://orcid.org/0000-0003-2158-3885)
- Thomas P. Ahern (ORCID: https://orcid.org/0000-0003-0440-8727)
- Anders Kjærsgaard (ORCID: https://orcid.org/0000-0001-9433-6442)
Institutions
- University of Vermont (US)
- University of Copenhagen (DK)
- Emory University (US)
- University of Southern Denmark (DK)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- BioRealm (United States) (US)
- Danish Breast Cancer Cooperative Group (DK)
Publication Details
- Journal
- Breast Cancer Research and Treatment
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1007/s10549-025-07719-1
- Citations
- 1
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- Aarhus Universitet
- Kræftens Bekæmpelse
- Danmarks Frie Forskningsfond
- Novo Nordisk Fonden
- National Cancer Institute