Targeting GPR84 to alleviate acute immune-mediated liver injury
Our findings suggest that GPR84 plays a pivotal role in immune-mediated liver injury, primarily through its expression on hematopoietic cells. Targeting GPR84, particularly with the antagonist GLPG1205, offers a promising therapeutic strategy for treating immune-related liver diseases.
Authors
- J Wang (ORCID: https://orcid.org/0009-0006-5938-168X)
- Yongzhen Chen
- Zhongping Su (ORCID: https://orcid.org/0000-0001-9823-6529)
- Yu-Jie Xu (ORCID: https://orcid.org/0000-0001-6378-607X)
- Jinshun Pan (ORCID: https://orcid.org/0000-0002-6394-7010)
- Yumeng Wang (ORCID: https://orcid.org/0000-0003-3612-9562)
- Qiang You (ORCID: https://orcid.org/0000-0003-3308-4127)
- Fengmeng Teng
- Yanan Zheng
- Shun Zheng (ORCID: https://orcid.org/0009-0004-3643-895X)
- S. C. Shen
- Chao Hu (ORCID: https://orcid.org/0000-0003-4596-1844)
- Haozhe Xu (ORCID: https://orcid.org/0009-0007-0064-2141)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jinhua Academy of Agricultural Sciences (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
- Jinhua Central Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s10020-025-01248-9
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sanming Project of Medicine in Shenzhen