Mechanistic Insights into HOTAIR-Driven ADAM17/NF-Κb Activation and Endothelial Dysfunction in LPS-Challenged HUVECs
The HOTAIR/miR-326/ADAM17 axis is a key regulator of inflammation, endothelial injury and barrier dysfunction during sepsis via modulation of TNF-α/NF-κB signaling, providing new insights into the mechanisms underlying endothelial injury in sepsis.
Authors
- Zixuan Shao
- Junbing He (ORCID: https://orcid.org/0000-0002-6916-4770)
- J Li (ORCID: https://orcid.org/0009-0003-7477-5968)
- Yufu He (ORCID: https://orcid.org/0009-0003-9525-8652)
- Yiming Shao (ORCID: https://orcid.org/0000-0002-4177-6038)
- Zhuoji Li
- Jingqi Zhang (ORCID: https://orcid.org/0009-0006-6258-9211)
- Qinghua Liu (ORCID: https://orcid.org/0000-0002-6385-5482)
Institutions
- Sun Yat-sen University (CN)
- Guangdong Medical College (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Immunological Investigations
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1080/08820139.2025.2503174
- Citations
- 2
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province