Genetic variants of SLC6A4 and risk of coronary artery disease: insights from North Indian population
Although, majority of the previous studies have evaluated the association of 5-HTTLPR biallelic polymorphism with CAD, our findings suggested that the tri-allelic 5-HTTLPR (rs25531) is a more reliable candidate than the bi-allelic 5-HTTLPR, as studying the bi-allelic version alone may generate association bias. Based on the results of this study, the rs25531 and STin2 polymorphisms indicated that the SLC6A4 gene does not contribute to the development of CAD in the population of the of Jammu region in Jammu and Kashmir state of India.
Authors
- Parvinder Kumar (ORCID: https://orcid.org/0000-0003-1039-6638)
- Santasree Banerjee (ORCID: https://orcid.org/0000-0003-2481-4562)
- Rakesh Kumar Panjaliya (ORCID: https://orcid.org/0000-0002-0015-6027)
- Minakashee Sharma
- Rohit Bhardwaj (ORCID: https://orcid.org/0000-0003-4005-4719)
- Jyotdeep Kour Raina (ORCID: https://orcid.org/0000-0001-9485-4725)
- R. V. Sharma (ORCID: https://orcid.org/0000-0001-6628-936X)
Institutions
- University of Jammu (IN)
- Jilin University (CN)
- Jilin Medical University (CN)
- Government Medical College (IN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s13023-025-03761-w
- Citations
- 1
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.81