Urea-sugar and thiourea-sugar diastereomers: synthesis, crystal structure and biological activities
From chiral sugar-derived (thio)ureas obtained, the compound 9 was found to be shown the highest activity against A549 cancer cell line. The compound 9, therefore, gave more promising results for future researches as anti-cancer agents. X-ray studies revealed that amide type hydrogens are playing important roles in anti-cancer activities.
Authors
- Adem Güner (ORCID: https://orcid.org/0000-0003-3295-3538)
- Özer Işılar (ORCID: https://orcid.org/0000-0001-7547-2537)
- Mustafa Tombul (ORCID: https://orcid.org/0000-0002-5115-5315)
- Adnan Bulut (ORCID: https://orcid.org/0000-0001-9322-0325)
- Onur Şahın (ORCID: https://orcid.org/0000-0003-3765-3235)
Institutions
- Kırıkkale University (TR)
- Sinop University (TR)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1080/17568919.2025.2504328
- Primary Topic
- Enzyme Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00