Effect of thymosin α1 on Immune response and organ function in acute aortic dissection surgery: PANDA II trial protocol
This multicenter randomized controlled trial evaluates the efficacy of thymosin alpha 1 (Tα1) supplementation in preventing organ dysfunction following acute type A aortic dissection (ATAAD) repair. Over 330 patients will be equally assigned to receive either Tα1 plus standard care or placebo with standard management. The primary endpoint involves calculating the difference in mean postoperative Sequential Organ Failure Assessment (SOFA) scores between groups, measured daily from postoperative days 7. By targeting post-operative immune system imbalance, this study aims to establish a novel therapeutic approach for reducing systemic inflammatory response syndrome (SIRS)-mediated organ injury and improving long-term outcomes in this high-risk population. Results will be disseminated through peer-reviewed publications and international conferences.<b>Trial registration</b>: ClinicalTrials.gov Registry (NCT05339529).
Authors
- Si-chong Qian (ORCID: https://orcid.org/0000-0003-4803-9855)
- Yingyuan Zhang (ORCID: https://orcid.org/0000-0001-9564-2353)
- Xuran Lu (ORCID: https://orcid.org/0000-0002-1707-1396)
- Guo-Liang Fan
- Hongjia Zhang (ORCID: https://orcid.org/0000-0002-5737-4084)
- Hong Liu (ORCID: https://orcid.org/0000-0002-4037-2787)
- Yiyao Jiang (ORCID: https://orcid.org/0000-0003-3217-4817)
- Xu Luo (ORCID: https://orcid.org/0000-0002-8394-8766)
- Wei Wang (ORCID: https://orcid.org/0000-0003-3651-3556)
- Xin Zhao (ORCID: https://orcid.org/0000-0003-2809-3221)
- Peng Xie
- Chao Ma (ORCID: https://orcid.org/0000-0003-1336-7998)
- Sheng Zhao
- Xueli Bai (ORCID: https://orcid.org/0000-0001-6005-8384)
- Zhihua Zeng
- Chuan Tang (ORCID: https://orcid.org/0009-0000-8773-7360)
- Xiangxiang Zheng
- Fuhua Huang
- Hong-Hua Yue
Institutions
- Tongji University (CN)
- Capital University (US)
- Nanchang University (CN)
- Xinjiang Medical University (CN)
- Tianjin University (CN)
- Capital Medical University (CN)
- Soochow University (TW)
- Xiamen University (CN)
- Sichuan University (CN)
- Kunming Medical University (CN)
- West China Hospital of Sichuan University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Yili Friendship Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- People's Hospital of Kaizhou District (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Jiangsu Province Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Southern Medical University (CN)
- Nanjing Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Future Cardiology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1080/14796678.2025.2505401
- Citations
- 1
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Beijing Nova Program