Comprehensive analysis and experiment validation of five cuproptosis-related genes in prognosis, immune infiltration and metabolic characterization of pancreatic cancer
Five CRGs relevant to pancreatic cancer prognosis were identified. Meanwhile, a new and accurate five CRGs prognostic model of pancreatic cancer was constructed. In addition, LIPT1 may promote proliferation, invasion and migration of pancreatic cancer cell lines. This may have a specific guiding value for future development of precise anti-cancer treatment strategies.
Authors
- Qiaoling Liao
- Xia Hu
- Honglin Quan
- Zheng Jiang (ORCID: https://orcid.org/0009-0004-7051-2391)
- Guojun Yuan
- Xiaoyan Tang (ORCID: https://orcid.org/0000-0002-5536-5117)
- LH Wu (ORCID: https://orcid.org/0009-0004-4233-7864)
- Kun Yang
- Quantong Deng (ORCID: https://orcid.org/0000-0002-6782-7577)
Institutions
- Mianyang Third People's Hospital (CN)
- Sichuan Mianyang 404 Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1371/journal.pone.0323458
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04