The differential burden of acute rhinovirus infections in children with underlying conditions
The prevalence of comorbidities was high in children with RV infections. Of those, asthma/atopy, prematurity and CHD were consistently associated with severe disease. Higher RV loads and bacterial co-infections, although infrequent, were also associated with worse clinical outcomes, suggesting the importance of defining clinical phenotypes for future targeted interventions.
Authors
- María Isabel Sánchez Códez
- Amy L. Leber (ORCID: https://orcid.org/0000-0002-3075-3586)
- Asunción Mejías (ORCID: https://orcid.org/0000-0002-5983-8006)
- Katherine Moyer
- Octavio Ramilo (ORCID: https://orcid.org/0000-0002-0565-5239)
- Isabel Benavente‐Fernández (ORCID: https://orcid.org/0000-0001-9276-1912)
Institutions
- St. Jude Children's Research Hospital (US)
- Nationwide Children's Hospital (US)
- Inova Children's Hospital (US)
- Biomedical Research and Innovation Institute of Cadiz (ES)
- Hospital Universitario Puerta del Mar (ES)
- Institute of Child and Mother Health (BD)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1371/journal.pone.0313237
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00