Molecular signatures of xenograft colorectal cancer in mice treated with topotecan: A mass spectrometry-based study
The findings provide a detailed characterization of metabolic alterations associated with topotecan treatment in CRC. These insights contribute to a better understanding of the drug's mechanism of action, which may help predict CRC patients' response to topotecan and guide the development of personalized therapeutic strategies.
Authors
- Mohammad H. Semreen (ORCID: https://orcid.org/0000-0002-0169-7538)
- Eman Abu‐Gharbieh (ORCID: https://orcid.org/0000-0002-5972-0681)
- Farman Matloob Khan
- Ruba A. Zenati (ORCID: https://orcid.org/0000-0002-0371-7440)
- Raafat El‐Awady (ORCID: https://orcid.org/0000-0002-7046-8587)
- Wafaa S. Ramadan (ORCID: https://orcid.org/0000-0002-7334-3093)
- Rizwan Qaisar (ORCID: https://orcid.org/0000-0001-8485-7172)
- Yasser Bustanji (ORCID: https://orcid.org/0000-0003-1315-0609)
- Hamza M. Al‐Hroub (ORCID: https://orcid.org/0000-0001-5621-9851)
- Rifat Hamoudi (ORCID: https://orcid.org/0000-0002-1402-0868)
- Yousra A. Hagyousif
- Waseem El‐Huneidi (ORCID: https://orcid.org/0000-0002-1580-2589)
- Nelson C. Soares (ORCID: https://orcid.org/0000-0003-2331-8532)
- Karem H. Alzoubi (ORCID: https://orcid.org/0000-0002-2808-5099)
- Ahmad Y. Abuhelwa (ORCID: https://orcid.org/0000-0002-4182-065X)
Institutions
- University of Jordan (JO)
- University of Sharjah (AE)
- Mohammed Bin Rashid University of Medicine and Health Sciences (AE)
- Nova Medical (United States) (US)
- National Institute of Health Dr. Ricardo Jorge (PT)
- University College London (GB)
- Universiti Teknologi MARA (MY)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Toxicology Reports
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.toxrep.2025.102045
- Citations
- 2
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- University of Sharjah