Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets
The findings of this study elucidate a mechanistic relationship among diabetes, inflammation, oxidative stress, and PQC impairment in the context of HFpEF. Therapeutic strategies that target these dysregulated pathways, including IL-6 inhibition, mitochondrial antioxidants, and chaperone-mediated protection, may enhance myocardial function in HFpEF patients with T2DM. Addressing these molecular dysfunctions could facilitate the development of novel interventions specifically tailored to the diabetic HFpEF population.
Authors
- Nazha Hamdani (ORCID: https://orcid.org/0000-0002-3053-0008)
- Árṕad Kov́acs (ORCID: https://orcid.org/0000-0002-8469-5764)
- Innas Sultana
- Marcel Sieme (ORCID: https://orcid.org/0000-0002-8253-879X)
- Loek van Heerebeek (ORCID: https://orcid.org/0000-0001-6718-2871)
- Wiebke Fenske
- Heidi Budde
- Péter Ferdinandy (ORCID: https://orcid.org/0000-0002-6424-6806)
- Domokos Máthé (ORCID: https://orcid.org/0000-0001-7343-0413)
- Kornélia Jaquet (ORCID: https://orcid.org/0000-0003-2706-6109)
- Andreas Mügge (ORCID: https://orcid.org/0000-0001-9548-6995)
- Peter Haldenwang (ORCID: https://orcid.org/0000-0003-1884-3498)
- Mustafa Kaçmaz (ORCID: https://orcid.org/0000-0002-8655-3882)
- Jan Wintrich (ORCID: https://orcid.org/0000-0001-6518-1453)
- Saltanat Zhazykbayeva
- Zoltán V. Varga (ORCID: https://orcid.org/0000-0002-2758-0784)
- Melissa Herwig (ORCID: https://orcid.org/0000-0003-3245-5504)
- Benjamin Sasko (ORCID: https://orcid.org/0000-0001-8157-9875)
- Simin Delalat
- Viktória É. Tóth
- Muchtiar Khan (ORCID: https://orcid.org/0009-0003-4925-399X)
- Wolfgang E. Schmidt
- Hersh Osman
- Ibrahim El-Battrawy
- Eda Göztepe
- Natalie Borgmann
- Gelareh Shahriari
Institutions
- Semmelweis University (HU)
- University of Debrecen (HU)
- University Hospitals of the Ruhr-University of Bochum (DE)
- Universitätsklinik Marien Hospital Herne (DE)
- OLVG (NL)
- Centre for Social Sciences (HU)
- St. Josef-Hospital (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s12933-025-02734-4
- Citations
- 24
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 33.32
Funders
- Ruhr-Universität Bochum