The Cardiovascular Magnetic Resonance Phenotype of Lamin Heart Disease
The CMR phenotype of LMNA carriers with preserved left ventricular systolic function consists of longer T<sub>2</sub>, higher serum troponin levels, higher extracellular volume, and impaired strain. CMR-derived focal fibrosis and strain biomarkers are prognostic, and future studies should explore their added clinical utility beyond the currently available MACE risk prediction tools. (The Deep Phenotype of Lamin A/C Cardiomyopathy; NCT03860454).
Authors
- Paolo Piras (ORCID: https://orcid.org/0000-0001-9832-2742)
- James Moon (ORCID: https://orcid.org/0000-0001-8071-1491)
- Iain Pierce (ORCID: https://orcid.org/0000-0001-8546-5023)
- Fiona Chan (ORCID: https://orcid.org/0000-0002-7380-7783)
- Konstantinos Savvatis (ORCID: https://orcid.org/0000-0003-1966-1880)
- Constantin‐Cristian Topriceanu (ORCID: https://orcid.org/0000-0001-5826-9617)
- Peter Kellman (ORCID: https://orcid.org/0000-0002-9875-6070)
- Hunain Shiwani (ORCID: https://orcid.org/0000-0002-0046-2884)
- Mashael Alfarih
- Saidi Mohiddin (ORCID: https://orcid.org/0000-0002-1031-4084)
- Gabriella Captur (ORCID: https://orcid.org/0000-0002-5662-0642)
- Richard P. Steeds (ORCID: https://orcid.org/0000-0001-5687-2535)
- Migma Dorji Tamang
- George Joy (ORCID: https://orcid.org/0000-0003-1467-5490)
- Paolo Emilio Puddu (ORCID: https://orcid.org/0000-0002-6191-7838)
- Andrea Barison (ORCID: https://orcid.org/0000-0001-9042-340X)
- Benjamin O’Brien (ORCID: https://orcid.org/0000-0001-7024-2337)
- Alun David Hughes (ORCID: https://orcid.org/0000-0001-5432-5271)
- Denis C. Ilie-Ablachim (ORCID: https://orcid.org/0009-0005-6984-2171)
- Steffen Erhard Petersen (ORCID: https://orcid.org/0000-0003-4622-5160)
- Catherine M. Banks
- William E. Moody (ORCID: https://orcid.org/0000-0002-2592-618X)
- Stephen Pettit (ORCID: https://orcid.org/0000-0001-5241-8431)
- Matt Webber
Institutions
- St Bartholomew's Hospital (GB)
- Outcomes Research Consortium (US)
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- Queen Elizabeth Hospital Birmingham (GB)
- Royal Papworth Hospital (GB)
- British Heart Foundation (GB)
- Deutsches Herzzentrum der Charité (DE)
- National Heart, Lung, and Blood Institute (US)
- MRC Unit for Lifelong Health and Ageing (GB)
- William Harvey Research Institute (GB)
- Fondazione Toscana Gabriele Monasterio (IT)
- University College London (GB)
- Charité - Universitätsmedizin Berlin (DE)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- JACC. Cardiovascular imaging
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.jcmg.2025.01.004
- Citations
- 8
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 11.11
Funders
- Society for Cardiovascular Magnetic Resonance
- Barts Charity
- National Institute for Health and Care Research
- British Heart Foundation
- British Medical Association