How does biological age acceleration mediate the associations of obesity with cardiovascular disease? Evidence from international multi-cohort studies
Biological age acceleration partially mediates the relationship between obesity and incident CVD. This temporal evidence firstly validated the mediation pathway based on international cohorts, emphasizing the importance of addressing biological aging processes in population aged 45-65 years while providing sex-specific obesity intervention strategies to prevent CVD.
Authors
- Lin Hu (ORCID: https://orcid.org/0000-0002-8853-2743)
- Zihuan Tang
- Teng Ma (ORCID: https://orcid.org/0000-0003-3864-6600)
- Pimin Gong (ORCID: https://orcid.org/0000-0001-8581-2806)
- Shuang Jiang (ORCID: https://orcid.org/0000-0003-2996-5562)
- Tao� Zhang (ORCID: https://orcid.org/0000-0003-4018-3393)
- Chunxia Yang (ORCID: https://orcid.org/0009-0000-8440-8481)
- Zongqi Chang
- Jiayuan Li (ORCID: https://orcid.org/0000-0002-6965-8877)
- Yang Chen (ORCID: https://orcid.org/0000-0001-7237-4579)
Institutions
- West China Medical Center of Sichuan University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s12933-025-02770-0
- Citations
- 16
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 55.91
Funders
- National Key Research and Development Program of China
- Chengdu Science and Technology Program