Micelle-Forming and Antimicrobial Properties of a Series of Bis-Quaternized Ammonium Compounds Based on DABCO Derivatives

A set of methods (tensiometry, conductometry, dynamic light scattering, spectroscopy, and fluorimetry) has been employed to study the self-assembly of long-chain bis-quaternized hydroxyethyl group-containing derivatives of 1,4-diazabicyclo[2.2.2]octane. The critical micelle concentrations, adsorption characteristics of the air–water interface, solubilization capacities with respect to poorly water-soluble OrangeOT dye, aggregation numbers, and sizes of aggregates have been determined. The influence of the structure (alkyl chain length and head group charge) of the studied compounds on their micelle-forming and antimicrobial properties, as well as hemolytic activity, has been determined.