SLAMF7 Restrains Pro-Inflammatory Macrophage Activation to Counteract Doxorubicin-Induced Cardiotoxicity
Doxorubicin-induced cardiotoxicity (DIC) poses a significant challenge in cancer treatment. This study investigated the role of SLAMF7 in DIC, particularly in macrophage-mediated inflammation. Using SLAMF7 knockout mice, we found that SLAMF7 deficiency exacerbates DIC and amplifies inflammatory responses. Mechanistically, SLAMF7 interacts with TNF receptor-associated factor 6 to attenuate nuclear factor κB signaling, reducing oxidative stress and proinflammatory cytokines. Notably, administering recombinant SLAMF7 protein effectively mitigated DIC. These findings underscore the critical role of SLAMF7 in protecting against DIC, positioning it as a promising therapeutic target.
Authors
- Fangyan Tian (ORCID: https://orcid.org/0009-0002-4425-8196)
- Jinghong Zhang (ORCID: https://orcid.org/0009-0000-3950-6752)
- Hongmin You
- Peiyuan Bai (ORCID: https://orcid.org/0000-0001-7812-2495)
- Chaobao Liu (ORCID: https://orcid.org/0000-0002-3049-713X)
- Haobo Weng (ORCID: https://orcid.org/0000-0002-4308-5361)
- Ao Liu (ORCID: https://orcid.org/0000-0002-6800-8012)
- Xuemei Wei (ORCID: https://orcid.org/0009-0005-1585-6674)
- Litao Wang (ORCID: https://orcid.org/0000-0002-7142-456X)
- Junbo Ge (ORCID: https://orcid.org/0000-0002-9360-7332)
- Lu Tang (ORCID: https://orcid.org/0009-0006-0592-9179)
- Shuning Zhang (ORCID: https://orcid.org/0000-0002-3015-1278)
- Xianhong Shu (ORCID: https://orcid.org/0009-0007-1887-5672)
- Ze-hao Zhuang
- Minmin Sun
Institutions
- Shanghai Medical College of Fudan University (CN)
- Nanchang University (CN)
- Guiyang Medical University (CN)
- Second Military Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Changhai Hospital (CN)
- Zhongshan Hospital (CN)
- Shanghai Institute of Hematology (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.jacbts.2025.02.015
- Citations
- 7
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 9.72
Funders
- National Natural Science Foundation of China