Magnetic resonance enterography to predict subsequent disabling Crohn’s disease in newly diagnosed patients (METRIC-EF)—multivariable prediction model, multicentre diagnostic inception cohort
Question Magnetic resonance enterography (MRE) is important for diagnosing and monitoring Crohn's disease (CD), but primary research evaluating its prognostic role is lacking. Findings Adding MRE findings at diagnosis to a multivariable model comprising clinical predictors did not improve the prediction of disabling CD within 5 years of diagnosis. Clinical relevance When tested in a prospective, multicentre trial, current MRE activity and damage scores at diagnosis did not reliably predict whether patients would subsequently develop disabling CD. Notwithstanding this finding, MRE remains an essential tool for diagnosis and monitoring.
Authors
- Samantha Baillie (ORCID: https://orcid.org/0000-0003-3280-0347)
- Steve Halligan (ORCID: https://orcid.org/0000-0003-0632-5108)
- Vivienne N. Eze
- Stuart A. Taylor (ORCID: https://orcid.org/0000-0002-6765-8806)
- P. J. Hamlin (ORCID: https://orcid.org/0000-0001-8080-1358)
- Anisha Bhagwanani
- Jing Yi Weng (ORCID: https://orcid.org/0000-0002-2875-4029)
- Rebecca Greenhalgh (ORCID: https://orcid.org/0000-0002-8890-2177)
- Thomas Parry
- Jamie Franklin
- Ailsa L Hart (ORCID: https://orcid.org/0000-0002-7141-6076)
- Mohamed Ahmed (ORCID: https://orcid.org/0000-0001-8048-8605)
- Andrew Plumb (ORCID: https://orcid.org/0000-0003-1322-5113)
- Gauraang Bhatnagar (ORCID: https://orcid.org/0000-0001-6607-1117)
- Richard Pollok (ORCID: https://orcid.org/0000-0001-6452-6763)
- Louise Lee
- Caroline S. Clarke (ORCID: https://orcid.org/0000-0002-4676-1257)
- Damian Tolan (ORCID: https://orcid.org/0000-0001-9895-9874)
- Antony Higginson (ORCID: https://orcid.org/0000-0002-9690-5394)
- William Hogg (ORCID: https://orcid.org/0000-0002-7571-3166)
- Alison Corr (ORCID: https://orcid.org/0000-0002-6902-7362)
- Tim Raine (ORCID: https://orcid.org/0000-0002-5855-9873)
- Maira Hameed (ORCID: https://orcid.org/0000-0002-6290-5695)
- Emma Helbren
- Jaymin Patel (ORCID: https://orcid.org/0000-0001-6698-5365)
- Simon P.L. Travis (ORCID: https://orcid.org/0000-0002-2690-4361)
- Roser Vega (ORCID: https://orcid.org/0000-0002-0116-7211)
- Ian Zealley (ORCID: https://orcid.org/0000-0001-8776-9071)
- Stuart Bloom (ORCID: https://orcid.org/0000-0002-6361-4662)
- Susan Mallett (ORCID: https://orcid.org/0000-0002-0596-8200)
- Shankar Kumar (ORCID: https://orcid.org/0009-0002-0742-815X)
- Arun Gupta (ORCID: https://orcid.org/0000-0003-0311-4284)
- James A. Stephenson
Institutions
- University College Hospital (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Maidstone and Tunbridge Wells NHS Trust (GB)
- St George's, University of London (GB)
- University of Hull (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Frimley Park Hospital (GB)
- St James's University Hospital (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Ninewells Hospital (GB)
- Queen Alexandra Hospital (GB)
- University of Oxford (GB)
- Portsmouth Hospitals NHS Trust (GB)
- Oxford BioMedica (United Kingdom) (GB)
- St Mark's Hospital (GB)
- University College London (GB)
- Bournemouth University (GB)
Publication Details
- Journal
- European Radiology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1007/s00330-025-11636-8
- Citations
- 3
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- University College London Hospitals NHS Foundation Trust
- Health Technology Assessment Programme