Radiation dosimetry of [11C]TZ1964B as determined by whole-body PET imaging of nonhuman primates
This nonhuman primate dosimetry study suggests intravenous doses up to 938 MBq of [<sup>11</sup>C]TZ1964B can be safely administered to human subjects for PET measurements of PDE10A activity. The tracer kinetic data is consistent with a hepatobiliary clearance pathway for the radiotracer.
Authors
- Jason Lenox-Krug
- Zhude Tu (ORCID: https://orcid.org/0000-0003-0325-835X)
- Joel S. Perlmutter (ORCID: https://orcid.org/0000-0003-3263-8917)
- Stephen M. Moerlein (ORCID: https://orcid.org/0000-0002-8897-092X)
- Baijayanta Maiti (ORCID: https://orcid.org/0000-0002-2583-4947)
- Richard A. Laforest (ORCID: https://orcid.org/0000-0002-0238-1439)
- Morvarid Karimi (ORCID: https://orcid.org/0009-0009-4670-4744)
- Scott A. Norris (ORCID: https://orcid.org/0000-0002-3835-0976)
- Mahdjoub Hamdi (ORCID: https://orcid.org/0000-0002-7647-3483)
- Tianyu Huang (ORCID: https://orcid.org/0000-0002-5607-4901)
- Nelson C. Goldman
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s13550-025-01221-x
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Parkinson Disease Association
- National Institutes of Health
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke