New IgG and IgA autoantibody specificities against DNA-binding and RNA-binding proteins discriminate systemic lupus erythematosus from health and non-lupus autoimmunity–could anti-LIN28A enhance precision in diagnostics?
Novel autoantibodies validated in this study may enhance diagnostics and molecular characterisation in SLE. The prominent IgA seroreactivity implicates important roles of mucosal tissues in SLE autoimmunity, warranting further investigation.
Authors
- Julius Lindblom
- Janique M Peyper (ORCID: https://orcid.org/0000-0001-5992-2470)
- Natalia Sherina (ORCID: https://orcid.org/0000-0001-6044-172X)
- Dionysis Nikolopoulos (ORCID: https://orcid.org/0000-0002-9894-6966)
- Guillermo Barturen (ORCID: https://orcid.org/0000-0003-2103-1028)
- Denis Lagutkin (ORCID: https://orcid.org/0000-0001-8000-6629)
- Marta E. Alarcón‐Riquelme (ORCID: https://orcid.org/0000-0002-7632-4154)
- Helena Idborg (ORCID: https://orcid.org/0000-0003-4041-4729)
- María Orietta Borghi (ORCID: https://orcid.org/0000-0001-8967-9678)
- Lorenzo Beretta (ORCID: https://orcid.org/0000-0002-6529-6258)
- Ioannis Parodis (ORCID: https://orcid.org/0000-0002-4875-5395)
- Per-Johan Jakobsson
Institutions
- Karolinska University Hospital (SE)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (ES)
- Sengkang General Hospital (SG)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.ard.2025.04.003
- Citations
- 6
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 10.01