Second-Line Antiretroviral Therapy for Children Living with HIV in Africa
Second-line ART regimens including TAF-emtricitabine and dolutegravir were effective for children, with no evidence of safety concerns. Ritonavir-boosted darunavir was also effective. (Funded by the European and Developing Countries Clinical Trials Partnership and others; CHAPAS-4 ISRCTN Registry number, ISRCTN22964075.).
Authors
- Simon Walker (ORCID: https://orcid.org/0000-0001-9185-4922)
- A. Sarah Walker (ORCID: https://orcid.org/0000-0002-0412-8509)
- Kusum Nathoo
- Khozya Zyambo (ORCID: https://orcid.org/0000-0002-3813-2784)
- Veronica Mulenga (ORCID: https://orcid.org/0000-0003-1843-8169)
- Alexander J. Szubert (ORCID: https://orcid.org/0000-0002-2082-0861)
- Kevin Zimba
- Anna Turkova (ORCID: https://orcid.org/0000-0002-7008-4145)
- David Burger
- Clare Shakeshaft
- Godfrey Musoro
- Helen McIlleron (ORCID: https://orcid.org/0000-0002-0982-6226)
- Alasdair Bamford (ORCID: https://orcid.org/0000-0003-4764-229X)
- Diana M. Gibb (ORCID: https://orcid.org/0000-0002-9738-5490)
- Shafic Makumbi (ORCID: https://orcid.org/0009-0009-2284-9017)
- Vivian Mumbiro
- Eva Natukunda (ORCID: https://orcid.org/0000-0002-2944-5412)
- Hilda Mujuru (ORCID: https://orcid.org/0000-0003-1615-3856)
- Yingying Zhang (ORCID: https://orcid.org/0000-0002-8419-0934)
- Cissy Kityo (ORCID: https://orcid.org/0000-0002-9286-7052)
- Rashidah Nazzinda
- Annabelle South (ORCID: https://orcid.org/0000-0001-8912-2001)
- Mutsa Bwakura‐Dangarembizi (ORCID: https://orcid.org/0000-0001-7751-6177)
- Wedu Ndebele
- Katja Doerholt (ORCID: https://orcid.org/0000-0001-5105-0970)
- Bwendo Nduna (ORCID: https://orcid.org/0000-0001-6613-4704)
- Lara Monkiewicz
- Mwate Mwamabazi
- Ibrahim Yawe
- Kyomuhendo Jovia Linda
- Chishala Chabala
- Monica Kapasa
- Joyce Lungu
- Anna Griffiths (ORCID: https://orcid.org/0000-0001-6512-5486)
- Victor Musiime
- Mary Nyathi
- Abbas Lugemwa
Institutions
- Radboud University Nijmegen (NL)
- University of Zimbabwe (ZW)
- University of Cape Town (ZA)
- Great Ormond Street Hospital (GB)
- Mpilo Central Hospital (ZW)
- University Teaching Hospital (ZM)
- Radboud University Medical Center (NL)
- National University of Science and Technology (ZW)
- University of Zambia (ZM)
- Infectious Diseases Research Collaboration (UG)
- Joint Clinical Research Centre (UG)
- University College London (GB)
- University of York (GB)
- Makerere University (UG)
- Medical Research Council (GB)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1056/nejmoa2404597
- Citations
- 14
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 19.55
Funders
- Gilead Sciences
- Medical Research Council
- Janssen Pharmaceuticals
- European and Developing Countries Clinical Trials Partnership