Oveporexton, an Oral Orexin Receptor 2–Selective Agonist, in Narcolepsy Type 1

In this phase 2 trial involving participants with narcolepsy type 1, oveporexton significantly improved measures of wakefulness, sleepiness, and cataplexy over a period of 8 weeks. (Funded by Takeda Development Center Americas; TAK-861-2001 ClinicalTrials.gov number, NCT05687903.).

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Publication Details

Journal
New England Journal of Medicine
Published
2025-05-14
DOI
https://doi.org/10.1056/nejmoa2405847
Citations
28
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
40.07
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article

Oveporexton, an Oral Orexin Receptor 2–Selective Agonist, in Narcolepsy Type 1

Todd J. Swick, Gert Jan Lammers, Tina M. Olsson, Philipp von Rosenstiel et al.
28 citations
New England Journal of Medicine
Sleep and Wakefulness Research
40.07
article

Oveporexton, an Oral Orexin Receptor 2–Selective Agonist, in Narcolepsy Type 1

Todd J. Swick, Gert Jan Lammers, Tina M. Olsson, Philipp von Rosenstiel, Mitsutaka Taniguchi, Ramin Khatami, Shinichiro Tanaka, Harisha Kadali, Melissa Naylor, Rachel Neuwirth, Rafael del Río Villegas, Christian von Hehn, Alice Cai, Anson K. Abraham, Yaming Hang, Yves A Dauvilliers, Hao Wang, Emmanuel Jean-Marie Mignot, Giuseppe Plazzi, Sarah Sheikh, Ellie Stukalin, Marta Lamberton
article en
28 citations

Abstract

In this phase 2 trial involving participants with narcolepsy type 1, oveporexton significantly improved measures of wakefulness, sleepiness, and cataplexy over a period of 8 weeks. (Funded by Takeda Development Center Americas; TAK-861-2001 ClinicalTrials.gov number, NCT05687903.).

New England Journal of MedicineVol. 392(19)
University of Modena and Reggio Emilia (IT), Inserm (FR), Université de Montpellier (FR), Leiden University Medical Center (NL), University Hospital of Bern (CH), Osaka Kaisei Hospital (JP), Hôpital Gui de Chauliac (FR), Hospital de Manises (ES), Istituto delle Scienze Neurologiche di Bologna (IT), Institute for Neurosciences of Montpellier (FR), Klinik Barmelweid (CH), Takeda (United States) (US), Universidad San Pablo (MX), Stichting Epilepsie Instellingen Nederland (NL), Stanford University (US)
Openalex Percentile: Top 0%
Sleep and Wakefulness Research
40.07
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