Oveporexton, an Oral Orexin Receptor 2–Selective Agonist, in Narcolepsy Type 1
In this phase 2 trial involving participants with narcolepsy type 1, oveporexton significantly improved measures of wakefulness, sleepiness, and cataplexy over a period of 8 weeks. (Funded by Takeda Development Center Americas; TAK-861-2001 ClinicalTrials.gov number, NCT05687903.).
Authors
- Todd J. Swick (ORCID: https://orcid.org/0000-0001-8563-6929)
- Gert Jan Lammers (ORCID: https://orcid.org/0000-0003-4755-7060)
- Tina M. Olsson (ORCID: https://orcid.org/0000-0002-7351-9140)
- Philipp von Rosenstiel (ORCID: https://orcid.org/0000-0003-1709-1271)
- Mitsutaka Taniguchi (ORCID: https://orcid.org/0000-0001-6485-2462)
- Ramin Khatami (ORCID: https://orcid.org/0000-0002-1092-6160)
- Shinichiro Tanaka (ORCID: https://orcid.org/0000-0003-4217-6859)
- Harisha Kadali
- Melissa Naylor (ORCID: https://orcid.org/0009-0006-7038-8276)
- Rachel Neuwirth
- Rafael del Río Villegas (ORCID: https://orcid.org/0000-0003-1652-4215)
- Christian von Hehn
- Alice Cai (ORCID: https://orcid.org/0009-0000-0442-0801)
- Anson K. Abraham (ORCID: https://orcid.org/0000-0002-9579-7483)
- Yaming Hang
- Yves A Dauvilliers (ORCID: https://orcid.org/0000-0003-0683-6506)
- Hao Wang (ORCID: https://orcid.org/0000-0003-4230-2077)
- Emmanuel Jean-Marie Mignot (ORCID: https://orcid.org/0000-0002-6928-5310)
- Giuseppe Plazzi
- Sarah Sheikh
- Ellie Stukalin
- Marta Lamberton
Institutions
- University of Modena and Reggio Emilia (IT)
- Inserm (FR)
- Université de Montpellier (FR)
- Leiden University Medical Center (NL)
- University Hospital of Bern (CH)
- Osaka Kaisei Hospital (JP)
- Hôpital Gui de Chauliac (FR)
- Hospital de Manises (ES)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Institute for Neurosciences of Montpellier (FR)
- Klinik Barmelweid (CH)
- Takeda (United States) (US)
- Universidad San Pablo (MX)
- Stichting Epilepsie Instellingen Nederland (NL)
- Stanford University (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1056/nejmoa2405847
- Citations
- 28
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 40.07