Photoinduced PhI(OAc)<sub>2</sub>-Mediated Cross-Dehydrogenative Heteroarylation of Aldehydes
Direct acylation of heteroarenes with aldehydes has been established through a photoinduced hypervalent iodine-mediated cross-dehydrogenative coupling reaction. The reaction proceeds through the in situ generation of nucleophilic acyl radicals from aldehydes via acyl C-H hydrogen atom transfer (HAT), followed by a Minisci-type reaction with heteroarenes. The developed reaction system proved to be suitable for cross-coupling a diverse range of heterocycles and aldehydes.
Authors
- Parthasarathy Gandeepan (ORCID: https://orcid.org/0000-0002-2483-7353)
- Lusina Mantry (ORCID: https://orcid.org/0000-0002-6046-753X)
Institutions
- Indian Institute of Technology Tirupati (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1021/acs.joc.5c00655
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- Ministry of Education, India
- Science and Engineering Research Board