Improvement of the Selectivity and Sensitivity of Analysis of Tetracycline Antibiotics Based on the ESI-MS Method with a Single-Quadrupole Mass Analyzer

The article describes methodological approaches that can be used to improve the performance characteristics of a single-quadrupole mass analyzer for studying the residual content of small organic substances in an aqueous medium using tetracycline antibiotics as an example. To improve the selectivity of the analysis, it is proposed to use optimal parameters of electron optics in the source (voltage across the fragmentor) in order to achieve a high yield of product ions. It is shown that the sensitivity of the analysis can be improved by summing the signals of all the formed product ions.