A comprehensive exploration of the impact and contribution of polygenic risk score on age at onset of 30 complex diseases
Higher PRS generally leads to earlier age at onset, which supports the potential role of PRS in screening high early-onset risk individuals susceptible to chronic diseases.
Authors
- Ping Zeng (ORCID: https://orcid.org/0000-0003-2710-3440)
- Yuxin Liu (ORCID: https://orcid.org/0000-0001-9753-2617)
- Fengjun Guan
- Pan Zhang (ORCID: https://orcid.org/0009-0003-0311-5161)
- Hua Lin (ORCID: https://orcid.org/0000-0001-5393-0322)
- Yue Xu (ORCID: https://orcid.org/0000-0002-5461-5495)
- Ke Wang (ORCID: https://orcid.org/0000-0003-4508-1302)
- Shuo Zhang (ORCID: https://orcid.org/0000-0002-3496-249X)
- Yu Yan (ORCID: https://orcid.org/0009-0009-6168-9933)
- Ting Wang (ORCID: https://orcid.org/0000-0001-5903-4633)
- Chu Zheng (ORCID: https://orcid.org/0000-0003-3309-208X)
- Xinyi Wang (ORCID: https://orcid.org/0000-0003-4255-6595)
- Yuchen Jiang (ORCID: https://orcid.org/0000-0003-4245-7490)
- Keying Chen
Institutions
- Xuzhou Medical College (CN)
- National Center for Chronic and Noncommunicable Disease Control and Prevention (CN)
- Liu Zhou Center for Disease Prevention and Control (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Public Health
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.puhe.2025.105754
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35