Methylprednisolone-induced Anaphylaxis in Acute Hepatitis B: A Case Report and Literature Review

Although glucocorticoids are commonly used to suppress allergic reactions, systemic glucocorticoid-induced anaphylaxis has also been reported. A man with acute hepatitis B was administered intravenous methylprednisolone to prevent the progression to liver failure. Shortly thereafter, the patient developed a rash and hoarseness, and methylprednisolone-induced anaphylaxis was diagnosed. The injection was stopped, an antihistamine was administered, and the symptoms resolved quickly. Subsequently, antiviral therapy and 9.9 mg/day of dexamethasone were initiated. The patient recovered completely without persistent hepatitis B virus infection. This case highlights the importance of recognizing glucocorticoid-induced anaphylaxis and provides insights into alternative treatment strategies for acute hepatitis B.