And One More Story

In 2025, after more than 20 years, the first non-opioid pain reliever suzetrigin was approved. This is a real breakthrough in pain management, which inspired the author to write this article. In addition to a brief summary of the current state of pain relief, it also provides a story of the discovery of this drug based on advances in understanding the function of voltage-gated sodium channels. The author also predicts possible further developments in the field of non-narcotic analgesics.