Design, synthesis and biological evaluation of aryl chalcone derivatives of pyridine-benzoxazole-pyimidine-oxazole as anticancer agents

A new library of aryl chalcone derivatives of pyridine-benzoxazole-pyimidine-oxazole ( 27a-j ) and their chemical structures were confirmed by analytical data. Further, all the newly synthesized compounds ( 27a-j ) were evaluated for their anticancer applications against human cancer cell lines by the MTT method. Here, the chemotherapeutic agent etoposide is used as a positive control. The obtained results were compared with etoposide. Most of the screened compounds displayed remarkable anticancer activity on all cell lines. Among them, five compounds exhibited more potent anticancer activity as compared to the positive control. Mainly, one compound, 27j, displayed superior activity on four cell lines. Furthermore, all the compounds displayed selective cytotoxicity against cancer cells but not against normal Vero cells (IC50 ≥19 μM), supporting the design method as a selective anticancer agents.