MicroRNA-669f-5p targeting deoxycytidinephosphate deaminase contributes to sevoflurane-induced cognitive impairments in aged mice via the TLR2/4–MyD88–NF-κB pathway
MicroRNA-669f-5p contributes to sevoflurane-induced cognitive impairment in aged mice by targeting Dctd and activating the TLR2/4-MyD88-NF-κB pathway. These findings provide new insights into potential therapeutic strategies for anaesthesia-related POCD.
Authors
- Yuanping Zhong
- Dongqin Chen
- Zhaoqiong Zhu (ORCID: https://orcid.org/0000-0001-5279-2984)
- Chunchun Tang (ORCID: https://orcid.org/0000-0002-5347-8919)
- Chao Zhang (ORCID: https://orcid.org/0000-0002-8163-9716)
- Li Yan Yuan (ORCID: https://orcid.org/0000-0002-7144-9441)
- Xue Zheng
Institutions
- Zunyi Medical University (CN)
- First People’s Hospital of Zunyi (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111381
- Citations
- 1
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 1.32