Electrochemical Synthesis of Ketones via Metal-Free Decarboxylative Coupling of Vinyl Azides and NHPI Esters
Abstract We introduce a metal-free method for C–C bond formation by coupling NHPI esters with vinyl azides through electrochemical synthesis. By converting carboxylic acids into radical-initiating NHPI esters, our approach achieves efficient C(sp³)–C(sp3) bond formation without needing metal catalysts. This method is highly adaptable, enabling the coupling of various NHPI esters with a broad range of vinyl azides, including those with halide or heteroatom substitutions.
Authors
- Satpal Singh Badsara (ORCID: https://orcid.org/0000-0002-9839-5113)
- Siddharth Sharma (ORCID: https://orcid.org/0000-0002-3102-6890)
Institutions
- Mohanlal Sukhadia University (IN)
- Banaras Hindu University (IN)
Publication Details
- Journal
- Synlett
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1055/a-2608-2142
- Citations
- 1
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Banaras Hindu University
- Science and Engineering Research Board
- Rashtriya Uchchatar Shiksha Abhiyan