From Bio- to Surface-Orthogonal Chemistry: Synthetic Routes to Functionalized Cyclooctynes
Abstract In this article, syntheses of functionalized cyclooctynes for bio- and surface-orthogonal applications are described and compared. Points of interest include their chemoselective reactivity in cycloadditions and their compatibility with transannular side reactions. Applications of cyclooctynes for layer-by-layer synthesis on the Si(001) surface are presented.
Authors
- Ulrich Koert (ORCID: https://orcid.org/0000-0002-4776-8549)
- Dominik Scharf (ORCID: https://orcid.org/0009-0009-5062-9556)
- M. Dürr (ORCID: https://orcid.org/0000-0002-4676-8715)
Institutions
- Philipps University of Marburg (DE)
- Justus-Liebig-Universität Gießen (DE)
Publication Details
- Journal
- Synlett
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1055/a-2608-1808
- Citations
- 1
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Deutsche Forschungsgemeinschaft