Resolvin D1-mediated cellular crosstalk protects against MASH
MASH is a growing healthcare burden worldwide. However, current treatments for MASH and its sequelae remain limited. Recent studies highlighted the therapeutic benefit of specialized pro-resolving mediators (SPMs), including RvD1, in liver diseases. However, the mechanisms underlying these beneficial effects are not well understood. Based on a series of co-culture primary cell experiments and unbiased transcriptomic analyses, we show that RvD1-mediated cellular crosstalk among hepatocytes and nonparenchymal cells protects against MASH progression. Our study provides a new mechanistic insight into the role of RvD1 in MASH and highlights its therapeutic potential to treat this condition.
Authors
- Amaia Navarro‐Corcuera (ORCID: https://orcid.org/0000-0001-6026-8285)
- Jerry E. Chipuk (ORCID: https://orcid.org/0000-0002-1337-842X)
- Neha Gupta (ORCID: https://orcid.org/0000-0001-8181-7378)
- Bruno Cogliati (ORCID: https://orcid.org/0000-0002-1388-7240)
- Oren Rom (ORCID: https://orcid.org/0000-0002-9272-086X)
- Brian E. Sansbury (ORCID: https://orcid.org/0000-0002-6339-2940)
- Haley Asplund
- Yiwei Zhu (ORCID: https://orcid.org/0000-0001-9789-7229)
- Scott L. Friedman (ORCID: https://orcid.org/0000-0003-1178-6195)
- Fanglin Ma (ORCID: https://orcid.org/0000-0002-7251-9544)
- Xin Huang (ORCID: https://orcid.org/0000-0002-6208-4751)
- Bishuang Cai (ORCID: https://orcid.org/0000-0002-2047-9923)
Institutions
- Louisiana State University (US)
- University of Louisville (US)
- Columbia University Irving Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101454
- Citations
- 3
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 3.96
Funders
- Irma T. Hirschl Trust
- Monique Weill-Caulier Trust
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Environmental Health Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development