Association of Plasma KIM-1, TNFR-1, and TNFR-2 With Cardiovascular Outcomes and All-Cause Mortality in Individuals With Chronic Kidney Disease: An Ancillary Analysis of SPRINT
In individuals with hypertension and nondiabetic CKD, associations of higher plasma KIM-1, TNFR-1, and TNFR-2 concentrations with CVD events were not independent of eGFR and albuminuria, whereas higher levels of plasma KIM-1 and TNFR-1 were independently associated with greater risk of all-cause mortality.
Authors
- Rebecca Scherzer (ORCID: https://orcid.org/0000-0002-1579-5390)
- Nicholas Wettersten (ORCID: https://orcid.org/0000-0002-6122-1152)
- Ronit Katz (ORCID: https://orcid.org/0000-0001-7723-7469)
- Joachim H. Ix (ORCID: https://orcid.org/0000-0002-8084-9869)
- Pranav Sandilya Garimella (ORCID: https://orcid.org/0000-0002-6016-4715)
- Alexander L. Bullen (ORCID: https://orcid.org/0000-0001-6864-0336)
- Michelle M. Estrella (ORCID: https://orcid.org/0000-0002-8902-9576)
- Teresa K. Chen (ORCID: https://orcid.org/0000-0003-0106-050X)
- Simon B. Ascher
- Kasey Campos (ORCID: https://orcid.org/0009-0004-4754-7254)
- Michael G. Shlipak
Institutions
- University of California, San Francisco (US)
- University of Washington (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- San Francisco VA Health Care System (US)
- University of California, Davis (US)
Publication Details
- Journal
- Kidney Medicine
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.xkme.2025.101024
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- Takeda Pharmaceuticals International