Myostatin Levels in <scp>SMA</scp> Following Disease‐Modifying Treatments: A Multi‐Center Study
This study demonstrates lower myostatin levels in SMA patients compared to controls. The association between myostatin levels, functional status, and SMA type suggests its possible role as a disease severity biomarker. The utility of myostatin as a biomarker for DMT response remains controversial; while we observed no significant increase in myostatin levels following treatment, we also did not observe the progressive reduction previously reported in untreated patients.
Authors
- Adele D’Amico (ORCID: https://orcid.org/0000-0003-2438-2624)
- Antonio Novelli (ORCID: https://orcid.org/0000-0002-2889-6967)
- Giorgia Coratti (ORCID: https://orcid.org/0000-0001-6666-5628)
- Fiorella Piemonte (ORCID: https://orcid.org/0000-0003-1825-9347)
- Giacomo P. Comi (ORCID: https://orcid.org/0000-0002-1383-5248)
- Eugenio Maria Mercuri (ORCID: https://orcid.org/0000-0002-9851-5365)
- Anna Capasso (ORCID: https://orcid.org/0000-0003-4061-4501)
- Maria Carmela Pera (ORCID: https://orcid.org/0000-0001-6777-1721)
- Chiara Bravetti
- Marika Pane (ORCID: https://orcid.org/0000-0002-4851-6124)
- Marianna Villa (ORCID: https://orcid.org/0000-0002-8537-4292)
- Stefania Paola Corti (ORCID: https://orcid.org/0000-0001-5425-969X)
- Emanuela Abiusi (ORCID: https://orcid.org/0000-0001-9028-012X)
- Silvia Baroni (ORCID: https://orcid.org/0009-0009-8528-7533)
- Sara Petrillo (ORCID: https://orcid.org/0000-0001-7891-760X)
- Francesco Danilo Tiziano (ORCID: https://orcid.org/0000-0002-5545-6158)
- Michela Catteruccia (ORCID: https://orcid.org/0000-0003-0785-5004)
- Chiara Arpaia (ORCID: https://orcid.org/0000-0001-6193-6249)
- Concetta Palermo
- Enrico Bertini
- Stefania Fiori
- Gianpaolo Cicala
- Salvatore Falqui
- Giulia Napoli (ORCID: https://orcid.org/0009-0006-0279-730X)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Parma (IT)
- University of Milan (IT)
- Agostino Gemelli University Polyclinic (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Centro Clinico Nemo (IT)
- Bambino Gesù Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Ferrari (Italy) (IT)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1002/acn3.70070
- Citations
- 1
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ministero della Salute