Long-Term Health-Related Quality of Life in People Living with HIV Who Present to Care with AIDS or Severe Immunodeficiency: The CoRIS AIDS Survivors Study
Our aim was to evaluate long-term health-related quality of life (HRQoL) in 253 people living with HIV (PLH) from the CoRIS cohort presenting to care with advanced HIV disease (AIDS or CD4 ≤ 100 cells/µL) and who had survived ≥ 5 years. Participants completed the WHOQOL-HIV-BREF and EQ-5D-5 L questionnaires. Clinical and immunological data were provided by the CoRIS at enrollment and on questionnaire completion. Linear repeated measures analyses assessed the evolution of immunological markers. Partial least squares structural equation modeling showed the longitudinal impact of baseline immunological markers on HRQoL. High baseline CD4 counts predicted higher WHOQOL-HIV-BREF independence scores (p = 0.021) and a marginally higher EQ-5D-5 L index value (p = 0.058), which was also associated with CD8 (p = 0.015). A higher CD4/CD8 ratio predicted lower scores on the WHOQOL-HIV-BREF 'spirituality, religion and personal belief' dimension (p = 0.006). Currently, PLH who present with advanced HIV disease achieve a moderate long-term HRQoL, with room for improvement.
Authors
- Melchor Riera (ORCID: https://orcid.org/0000-0002-0887-8710)
- Núria Espinosa (ORCID: https://orcid.org/0000-0003-2249-2352)
- Julia Portilla-Tamarit (ORCID: https://orcid.org/0000-0003-0881-9646)
- Sergio Reus (ORCID: https://orcid.org/0000-0002-3320-9754)
- Joaquín Portilla (ORCID: https://orcid.org/0000-0002-3676-9511)
- Juan Eduardo Samur‐San Martin (ORCID: https://orcid.org/0000-0002-9783-1147)
- Irene Portilla (ORCID: https://orcid.org/0000-0002-2187-8731)
- Mar Masiá (ORCID: https://orcid.org/0000-0001-9878-2458)
- María José Fuster‐RuizdeApodaca (ORCID: https://orcid.org/0000-0003-4304-7194)
- Sònia Calzado (ORCID: https://orcid.org/0000-0002-2975-6448)
- Enrique Bernal (ORCID: https://orcid.org/0000-0002-4041-0579)
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- University of Alicante (ES)
- Universidad Nacional de Educación a Distancia (ES)
- Instituto de Salud Carlos III (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Sociedad Española de Medicina de Familia y Comunitaria (ES)
- Spanish Clinical Research Network (ES)
- Hospital General Universitario de Elche (ES)
- Hospital Reina Sofía de Murcia (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Spanish Society of Hematology and Hemotherapy (ES)
- Hospital Universitario Son Espases (ES)
- Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) (ES)
- Deleted Institution
Publication Details
- Journal
- AIDS and Behavior
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1007/s10461-025-04730-x
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad de Alicante