Combined detection of P53, Ki67, P504S, and IMP3: Diagnostic implications for gastric cancer and precursor lesions
P504S is highly expressed in LGD and is associated with the Ki67 "polarity" expression pattern. IMP3 is highly expressed in HGD/AC and is correlated with the <i>P53</i> mutation expression pattern. The combined detection of P504S with Ki67 and IMP3 with P53 increased the diagnostic sensitivity for LGD and HGD/AC, respectively. The rational use of P504S, Ki67, IMP3, and p53 can help distinguish gastric cancer and precancerous lesions, improving the early cancer diagnosis rate.
Authors
- Lanfang Miao (ORCID: https://orcid.org/0009-0006-5197-2231)
- Jun-Kuo Li
- Xiongming Du (ORCID: https://orcid.org/0000-0003-1704-2568)
- Haijun Yang (ORCID: https://orcid.org/0000-0003-3273-3455)
- Yi‐Chun Zhu (ORCID: https://orcid.org/0000-0002-0873-2957)
- Jinyan Shen (ORCID: https://orcid.org/0000-0002-1955-093X)
- Hui Hua (ORCID: https://orcid.org/0000-0002-9574-6926)
- Nan Xu (ORCID: https://orcid.org/0009-0006-5291-3591)
- Yuanyuan Sun (ORCID: https://orcid.org/0000-0003-4593-7895)
- Mei Guo (ORCID: https://orcid.org/0000-0001-6954-8873)
Institutions
- The Fifth People's Hospital of Anyang (CN)
- Anyang Tumor Hospital (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.4251/wjgo.v17.i5.105604
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00