Simvastatin inhibits proliferation and migration, promotes oxidative stress and ferroptosis in colon cancer
Simvastatin effectively inhibited the proliferation and migration of colon cancer cells and promoted apoptosis through the modulation of key targets, such as <i>SERPINE1</i> and the cGMP/PKG signaling pathway.
Authors
- Lei He (ORCID: https://orcid.org/0000-0002-4078-2081)
- Haoran Zhao (ORCID: https://orcid.org/0000-0003-2842-3526)
- Meng Li (ORCID: https://orcid.org/0000-0003-0369-5867)
- Qiang Leng (ORCID: https://orcid.org/0000-0002-9510-1773)
- Zhimin Fan (ORCID: https://orcid.org/0000-0001-6503-869X)
- Ying Liu (ORCID: https://orcid.org/0000-0002-3328-026X)
- Ting Lu (ORCID: https://orcid.org/0000-0002-1611-9909)
- Hao Ge
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.4251/wjgo.v17.i5.104522
- Citations
- 3
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81