Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway
These findings suggest that MSC-EVs have the potential to effectively mitigate the pathogenesis of COVID-19 by targeting the JAK/STAT signaling pathway. Further research is needed to fully understand the mechanisms underlying the therapeutic effects of MSC-EVs and their clinical application in combating the COVID-19 pandemic.
Authors
- Omnia A. Badr (ORCID: https://orcid.org/0000-0002-2318-9630)
- Nehal M. Elsherbiny (ORCID: https://orcid.org/0000-0001-5167-3377)
- Rabab F. Salim (ORCID: https://orcid.org/0000-0003-4139-4678)
- Ali A. Rabaan (ORCID: https://orcid.org/0000-0002-6774-9847)
- Gianpiero Di Leva (ORCID: https://orcid.org/0000-0001-6759-8682)
- Ahmed Badawy (ORCID: https://orcid.org/0000-0002-4966-3839)
- Ahmed N. Abdallah (ORCID: https://orcid.org/0000-0003-0517-6470)
- Sabry Younis Mahmoud (ORCID: https://orcid.org/0000-0001-9599-4754)
- Ashraf Shamaa
- Gamal Othman
- Hajir A. Al Saihati
- Nesrine Ebrahim
- Zahraa Alali
- Arigue A Dessouky
Institutions
- Northern Border University (SA)
- Alfaisal University (SA)
- Cairo University (EG)
- Zagazig University (EG)
- Benha University (EG)
- Saudi Aramco Medical Services Organization (SA)
- University of Haripur (PK)
- University of Hafr Al-Batin (SA)
- National Research Centre (EG)
- Almaarefa University
- Keele University (GB)
- University of Tabuk (SA)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s13287-025-04284-8
- Citations
- 3
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- University of Hafr Al Batin