1,2,3-Triazole‑gold(I)-triethylphosphine derivatives of nutrients as new antimicrobials against antibiotic resistant Gram-positive pathogens
The ongoing rise of bacterial resistance against antibiotics is an incentive to develop radically new antibacterial molecules. Innovative organo-gold(I) antibacterial compounds were synthesized by click chemistry with triethylphosphine‑gold(I) azides and alkyne-functionalized metabolites like amino acids, nicotinic acid and biotin. The resulting organo‑gold(I) compounds exhibited remarkable activities against a panel of Gram-positive pathogens (Staphyloccocus sp., Enterococcus sp. and Clostridium difficile) but failed to inhibit the growth of Gram-negative bacilli (e.g., Escherichia coli) under the conditions used (8 μg. mL<sup>-1</sup> maximum).
Authors
- Gaëtan L. A. Mislin (ORCID: https://orcid.org/0000-0002-5646-3392)
- Alexandre Steffen
- Mathieu Michaut
- Françoise Hoegy
- Christophe Morice (ORCID: https://orcid.org/0000-0002-5135-3426)
- Jean‐Marie Contreras
- Patrick Plésiat
Institutions
- Centre National de la Recherche Scientifique (FR)
- Laboratoire Chrono-Environnement (FR)
- Biotechnologie et Signalisation Cellulaire (FR)
Publication Details
- Journal
- Bioorganic & Medicinal Chemistry Letters
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.bmcl.2025.130276
- Citations
- 1
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Agence Nationale de la Recherche
- Centre National de la Recherche Scientifique