Ferulic acid suppresses guinea pig ileal longitudinal smooth muscle contractions by inhibiting voltage-dependent Ca2+ channels
We investigated the effects of ferulic acid (FA) on contractions in guinea pig ileal longitudinal smooth muscle (ILSM). FA (3 × 10<sup>-4</sup>-3 × 10<sup>-3</sup> M) inhibited ILSM contractions induced by acetylcholine, histamine, prostaglandin F<sub>2α</sub>, and serotonin concentration-dependently, reversibly, and noncompetitively with pD'<sub>2</sub> values of ∼3. FA also concentration-dependently and reversibly inhibited KCl-induced ILSM contractions. FA (10<sup>-3</sup> M), which inhibited ILSM contractions by ∼50 %, also reduced verapamil-sensitive, KCl-induced intracellular Ca<sup>2+</sup> increases in A7r5 cells by ∼35 %. These results suggest that FA inhibits ILSM contraction, primarily through the reversible inhibition of Ca<sup>2+</sup> influx via voltage-dependent Ca<sup>2+</sup> channels.
Authors
- Masakazu Enomoto
- Yoshio Tanaka (ORCID: https://orcid.org/0000-0002-8341-3809)
- Kento Yoshioka (ORCID: https://orcid.org/0000-0003-1701-3759)
- Keisuke Obara (ORCID: https://orcid.org/0000-0001-9226-4086)
- Fumiaki Makino (ORCID: https://orcid.org/0000-0001-9512-7087)
- Shin-Ichiro Ichihara
- Naho Takazakura
- Aya Shimada
- Wakaba Kinami
Institutions
- Toho University (JP)
Publication Details
- Journal
- Journal of Pharmacological Sciences
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.jphs.2025.05.012
- Citations
- 2
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- Japan Society for the Promotion of Science