Postoperative brain abscess of Prevotella Oris due to skull base surgery: Case report and literature review

Prevotella Oris is a gram-negative anaerobic bacillus that is rarely encountered in clinical practice. Brain abscesses resulting from this bacterium are exceedingly uncommon, however the advent of skull base surgery has facilitated intracranial infections caused by this bacterium. The challenging conditions of anaerobic bacterial cultures make it difficult to accurately discover the causing pathogen. However, this can be achieved by the use of metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF). In this case study, we present the case of a 29-year-old male who experienced the development of a brain abscess and hydrocephalus as a result of an intracranial infection caused by the genus Prevotella Oris following skull base surgery. The patient's treatment was guided by the findings of a metagenomic test, and the patient's condition showed improvement after a period of two months. Postoperative infections following skull base surgery are extremely uncommon, and specifically, there have been no known cases of brain abscesses caused by Prevotella Oris . This report presents the first documented case of Prevotella Oris . infection resulting from skull base surgery, highlighting the significance of preoperative prophylactic measures and the application of mNGS. This highlights the significance of preoperative prophylaxis and the use of mNGS. The mechanism of Prevotella oris infection and resistant. The potential diagnostic value and applications of mNGS. • The initial occurrence of Prevotella Oris infection resulting from skull base surgery. • The mechanism of Prevotella oris infection and resistant. • The potential diagnostic value and applications of mNGS.