Polygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms
Individuals who experience ACEs and, to a lesser extent, those with higher PGS for SUDs, are susceptible to more severe withdrawal symptoms. In EUR individuals, there was evidence for a complex interplay of genetic and environmental factors on substance withdrawal. These exploratory findings require independent validation.
Authors
- Angela Han (ORCID: https://orcid.org/0009-0009-1514-4799)
- Christal N. Davis (ORCID: https://orcid.org/0000-0003-3974-5598)
- Joel Gelernter (ORCID: https://orcid.org/0000-0002-4067-1859)
- Richard Feinn (ORCID: https://orcid.org/0000-0002-4158-7640)
- Henry R. Kranzler (ORCID: https://orcid.org/0000-0002-1018-0450)
- Zeal Jinwala (ORCID: https://orcid.org/0009-0005-5062-0827)
- Jackson F SooHoo
Institutions
- VA Connecticut Healthcare System (US)
- Philadelphia VA Medical Center (US)
- Quinnipiac University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Drug and Alcohol Dependence
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.drugalcdep.2025.112712
- Primary Topic
- Child and Adolescent Psychosocial and Emotional Development
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- VISN 4 Mental Illness Research, Education, and Clinical Center
- National Institute on Alcohol Abuse and Alcoholism