Decreased Fecal Nicotinamide and Increased Bacterial Nicotinamidase Gene Expression in Ulcerative Colitis Patients
These findings suggest that gut microbiota dysbiosis contributes to reduced vitamin B3 metabolism in UC patients. The study highlights the potential of replenishing vitamin B3 metabolic pathways as a novel therapeutic approach for UC treatment.
Authors
- Eiji Kondo
- Tomohiro Shimizu (ORCID: https://orcid.org/0000-0001-6760-3066)
- Naoya Sakamoto (ORCID: https://orcid.org/0000-0003-0061-059X)
- Norimasa Iwasaki (ORCID: https://orcid.org/0000-0002-5496-4046)
- Shinji Fukuda (ORCID: https://orcid.org/0000-0003-0771-1158)
- Ryodai Yamamura (ORCID: https://orcid.org/0000-0002-9342-7702)
- Tomoyoshi Soga (ORCID: https://orcid.org/0000-0001-9502-2509)
- Masahiro Sonoshita (ORCID: https://orcid.org/0000-0003-2890-336X)
- Akiko Tamakoshi (ORCID: https://orcid.org/0000-0002-9761-3879)
- Keiya Aoyama
- Takehiko Katsurada (ORCID: https://orcid.org/0000-0002-7400-2514)
- Daisuke Takahashi (ORCID: https://orcid.org/0000-0001-8624-1160)
Institutions
- Hokkaido University of Science (JP)
- Yamagata University (JP)
- University of Tsukuba (JP)
- Kanagawa Institute of Technology (JP)
- Keio University (JP)
- Hokkaido University (JP)
- Juntendo University (JP)
- Hokkaido Sapporo Kiyota High School (JP)
- Tsukuba Medical Center Hospital (JP)
- Hokkaido University Hospital (JP)
- Kanagawa Industrial Technology Center (JP)
- Hokkaido Institute of Public Health (JP)
- National Institute of Technology, Tsuruoka College (JP)
- Skyworks Solutions (United States) (US)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1093/ibd/izaf092
- Citations
- 3
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 4.19