The relationship of the variant of joint syndrome with provoking factors in the onset of juvenile psoriatic arthritis
Juvenile psoriatic arthritis is a chronic inflammatory disease of the peripheral joints, spinal joints and entheses, which occurs in 10–25% of patients with psoriasis. Studying the features of the juvenile psoriatic arthritis’s debut will increase early diagnosis and will help to avoid disability, socialize and integrate the child into society.Objective. The purpose of the work is to identify the relationship between the variant of the articular syndrome of juvenile psoriatic arthritis at the onset of the disease and the provoking factor of the disease.Material and methods. 155 patients with an established diagnosis of juvenile psoriatic arthritis were examined. To analyze the data, universal nonparametric (randomization-permutation) algorithms for constructing confidence intervals (CI) were used. Comparison of groups by binary and categorical features is performed using the exact Fisher criterion for tables 2×2 or the exact Fisher–Freeman– Holton criterion for tables r×c. The reliability was assessed (p<0.05) and by the nonparametric Mann–Whitney method (p<0.05).Results. The relationship with the variant of the onset of articular syndrome with the provoking factor of the disease was revealed: in the rheumatoid-like variant, the proportion of patients with stress (p<0.005) acting as a trigger is higher; in spondyloarthritis, the proportion of the infectious factor is higher (p<0.005).Conclusion. The relationship with the variant of the onset of articular syndrome with the provoking factor of the disease was revealed. Stress was the leading provoking factor in our patients, and the infectious factor was the second most common.
Authors
- Н.А. Геппе (ORCID: https://orcid.org/0000-0003-0547-3686)
- I.M. Farber (ORCID: https://orcid.org/0000-0001-6919-6732)
- М. Н. Николаева (ORCID: https://orcid.org/0000-0002-6696-1950)
- I. M. Korsunskaya (ORCID: https://orcid.org/0000-0002-6583-0318)
- E. Yu. Afonina (ORCID: https://orcid.org/0000-0001-9643-5567)
- Lusine Khachatryan (ORCID: https://orcid.org/0000-0002-0218-9092)
- С. Н. Чебышева (ORCID: https://orcid.org/0000-0001-5669-4214)
- А.V. Meleshkina (ORCID: https://orcid.org/0000-0002-4125-0335)
- V. V. Sobolev
- Ya. G. Ambarcumova
Institutions
- Sechenov University (RU)
- Center for Theoretical Problems of Physicochemical Pharmacology (RU)
Publication Details
- Journal
- Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)
- Published
- 2025-05-14
- DOI
- https://doi.org/10.21508/1027-4065-2025-70-2-52-58
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00